2) P2Y12 Assay. 전혈 검체 2mL을 카트리지와 결합시켜 카트리지 안의 첫번째 first Detection chamber내에서는 작용물질인 ADP, prostaglandin E1 (PDE1)와 섬유소원이 코팅되어 있는 미이크로비드와 응집을 일으킨다. Please insert in Directory of Services LABORATORY ALLIANCE of Central New York, LLC Update on Plavix (Clopidogrel) Response Assay Platelet Function P2Y12 Patients who have undergone placement of coronary stents require dual antiplatelet therapy with Plavix and aspirin to prevent the serious complication of in-stent thrombosis. Test results are reported in P2Y12 Reaction Units (PRU) which indicate the amount of ADP-mediated aggregation specific to the platelet P2Y12 receptor and is used to measure the effects of anti-platelet drugs specific to this receptor, such as clopidogrel. Learn the current clinical guidelines for transfusion of platelets to patients with thrombocytopenia or platelet function defects. 2 Approved Revised Ticlopidine, due to a number of severe adverse events including neutropenia, agranulocystosis, and Clinlabnavigator reviews testing for platelet inhibition by clopidogrel, prasugrel and ticagrelor using the VerifyNow P2Y12 sytem. 3 Approved Revised , , platelet activation by ADP binding to the P2Y12 receptor (the inhibition target for clopidogrel). Warnings/Precautions. Concerns related to adverse effects: • Bleeding: Clopidogrel increases the risk of bleeding. Use is contraindicated in patients with active pathological bleeding (eg, peptic ulcer, intracranial hemorrhage). Learn about Plavix (Clopidogrel Bisulfate) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.